HORDB

ID: hor002165
Uniprot ID: P01318
Protein name: Insulin A chain
Gene name: INS
Organism: Ovis aries (Sheep)
Family: Insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005159 insulin-like growth factor receptor binding; GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction; GO:1903576 response to L-arginine; GO:1904927 cellular response to palmitoleic acid
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: GIVEQCCAGVCSLYQLENYCN
Length: 21
Propeptide: MALWTRLVPLLALLALWAPAPAHAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCAGVCSLYQLENYCN
Signal peptide: MALWTRLVPLLALLALWAPAPAHA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002165_AF2.pdb

hor002165_ESM.pdb

Mass:	266657	Formula:	C96H149N25O33S4
Absent amino acids:	DFHKMPRTW	Common amino acids:	C
pI:	3.61	Basic residues:	0
Polar residues:	11	Hydrophobic residues:	6
Hydrophobicity:	33.81	Boman Index:	-1001
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	88.1
Instability Index:	701.9	Extinction Coefficient cystines:	3230
Absorbance 280nm:	161.5